Liverpool forward Mohamed Salah will now join Roberto Firmino to miss Tuesday’s Champions League semi-final second leg with Barcelona through injury.
Salah was taken off the pitch on a stretcher after an aerial collision with Newcastle keeper Martin Dubravka during Saturday’s 3-2 win.
Manager Jurgen Klopp has now said concussion will keep Salah out, as Liverpool look to overhaul a 3-0 deficit at Anfield.
Firmino missed the win over Newcastle with a muscle injury.
“Two of the world’s best strikers are not available tomorrow night and we have to score four goals,” said Klopp.
“It doesn’t make life easier but as long as we will try for 90 minutes to celebrate the Champions League campaign to give it a proper finish.
“That’s the plan. If we can do it, wonderful. If we can’t do it, let’s fail in the most beautiful way.”
Salah seemed to be in tears when he was carried from the pitch at St James’ Park but Klopp says the Egypt international now feels “OK”.
“It’s not good enough from a medical point of view,” Klopp added.
“He is desperate to play but we cannot do it.
“It’s a concussion. That means he would not even be allowed to play.”
Klopp is hopeful Salah will be able to play in Liverpool’s final Premier League game of the season against Wolves at Anfield on Sunday, where the Reds could win the title for the first time since 1990.